The world of scientific research is dense and vast not unlike a thick jungle. There are so many sources of information coming from multiple science channels that it has become hard to navigate through it all. We created the Innovation Hub so that those of you traveling into the jungle of drug discovery can explore it with ease and find the latest and greatest innovations.
Full access to the Innovation Hub is limited to our current users, but each month we share a sampling of its content through these monthly blog posts. You can see our top 8 picks for this month straight from the Innovation Hub below:
3D Triculture Breast Cancer Model
Use tricultures of breast cancer cell lines, hMSCs, and endothelial tubules for evaluating breast cancer progression.
In this model, three different cell types are cultured together: breast cancer cell line, human umbilical vein endothelial cells, and human adipose-derived mesenchymal stem cells. The triculture model closely mimics the extracellular environment, cellular architecture, and behavior of actual tumors.
LRRK2 Cell Lines – an in vitro model for Parkinson’s disease
Use genomically altered cell lines to develop therapies aimed at correcting or lowering deleterious LRRK2 signaling.
These cell lines overexpress mutant versions (linked to Parkinson’s disease) of full-length LRRK2. This tool will help researchers better understand Parkinson’s disease mechanisms and develop new therapies.
Assess small blood vessels under close-to in vivo conditions.
This platform loads and immobilizes small arteries within a microfluidic channel, where they can be maintained and analyzed under near-in vivo physiological conditions.
Use the CRISPR-Cas9 alternative for mammalian genome editing.
This new DNA-editing tool works analogously to CRISPR/Cas9, which has revolutionized research in genome editing. CRISPR/Cpf1 is potentially better than CRISPR/Cas9 as Cpf1 is smaller and simpler than Cas9, which simplifies delivery to the cells whose genes need modifying.
Manufacture long-length DNA constructs simultaneously in a single reaction.
This DNA synthesis platform will help researchers translate vast information from genome sequencing projects into quickly actionable results and reduce the massive discrepancy between the annual global capacity for “reading” DNA (sequencing) and “writing” DNA (synthesis).
Regenova® 3D Bio Printing
Fabricate 3D tissue from primary cells using the Regenova 3D Bio Printer.
This 3D Bio Printer facilitates the fabrication of 3D cellular structures by placing cellular spheroids in fine needle arrays (“Kenzan method”) according to pre-designed 3D data.
Single Fluorescent Protein-based Biosensors
Detect Gi, Gs, and Gq-coupled pathways of GPCR signaling.
This new Gi assay for live primary cells uses a constitutively active mutant Gs to increase cAMP levels instead of disrupting the cell with Forskolin or IBMX.
Bacterial Cytological Profiling (BCP) Platform
Determine the mode of action for newly discovered antimicrobial compounds.
The BCP platform can be used to rapidly identify and study the mechanism of action (MOA) for compounds active against Gram positive or Gram negative bacteria.
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