Disease Models

Building IND-enabled preclinical packages: Accelerating radiopharmaceutical development through integrated translational science

In Vivo Study: From Study Design, Execution to Pathology Assessment in One Laboratory at APS

Immortalized vs. Primary Cells: Choosing the Right Model for Your Research

The Science of the "Gut Feeling": Why Techs are a Lab's Best Diagnostic Tool

Cell Line-Derived Xenografts: A Reliable Platform for Preclinical Cancer Drug Testing

Five Reasons Leading CNS Programs Rely on BrainXell for Custom iPSC Models

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Improving Translational Decision-Making through Disease-Relevant Preclinical Models in Pulmonary Fibrosis and Pain Drug Discovery

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From Skull to Deep Brain: Exploring Brain Dynamics with Intravital Imaging

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Engineering Neuromodulation for Cardiovascular Instability

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Advancing Skin Research: A Scalable 3D Human Skin Organoid Model for Skin Barrier Function and Injury Screening

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Enhancing Clinical Predictability through Human Disease-relevant Preclinical Models in CNS and Muscle Drug Discovery

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Visualizing Lipid Control of Drug Binding in Membrane Proteins at High Resolution

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New Approach Methodologies (NAMs): Key Considerations and Applications

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Improving Preclinical Decision-Making in Obesity and CKD with Translational In Vivo Phenotyping

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Detecting Early Synaptic Failure in Prion Disease Using Organoid Models

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Skeletal Muscle Circadian Clocks: Keeping Time for Systemic Health

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Functional Ultrasound Demonstration and Live Q&A: Iconeus One, a Pioneer in Real-Time Whole-Brain Imaging

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Bridging Mouse Models and Human Inflammatory Bowel Disease: in vivo Pharmacology, Histology and Biomarkers

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Illuminating the Brain: Advances in Neurobiology

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Fulfilling the Gap: Innovative Critical Reagents for Non-Human Primate Preclinical Studies

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Advancing ADC Development: Leveraging AI and Translational Preclinical Models to Improve Clinical Predictability

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Precision in Human Biological Samples: Leveraging Regulatory Rigor and Deep Data for Advanced Disease Research

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Opening a New Window: Stable Long-Term Imaging of Dura Mater-Transplanted Pancreatic Islets in Awake Mice

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The Expert Approach to Preclinical Indirect Calorimetry Experiments

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Photoreceptor Cell Therapy to Treat Advanced Retinal Degeneration

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Clinical Applications of Optical Cerebral Blood Flow Imaging

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Using ALS Patient-Derived Motor Neurons to Study TDP-43 Mislocalization

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Gene-Agnostic Gene Therapy to Preserve Vision

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Vevo Ask The Experts: Oncology Imaging

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hiPSC-Cardiomyocyte Platforms Enabling Comprehensive Cardiac Toxicity and Drug Efficacy Evaluation

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Noninvasive Imaging of Liver Disease by MRI and Photoacoustic Ultrasound

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Transcranial Focused Ultrasound Neuromodulation of the Default Mode Network in the Treatment of Depression and Promotion of Wellness

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In Vivo panCAR Therapy Using Circular RNA for the Treatment of Autoimmune Disease

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FUJIFILM VisualSonics' Advanced Cardio Symposium

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Recent Advances in Diagnosis of Autonomic Syncope

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Building New Approach Methodologies (NAMs) and Complex In Vitro Assays

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Uniting biology and digital drug discovery to identify new therapeutic opportunities in neurodegeneration

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Exploring the iPSC-Derived Neuronal-Glia Co-culture System: A Powerful Drug Discovery Platform for Studying Neurodegenerative Diseases

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Redox Regulation of Skeletal Muscle: A Journey from Liverpool to the International Space Station

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Advances in Preclinical Research using Human Co-culture Models: Applications in Immunology, Infectious Disease, and Oncology

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Reprogramming Mouse Fibroblasts Into Induced Cardiomyocytes: Age-Related, Metabolic, and Epigenetic Barriers

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RIP1 Inhibition Protects Retinal Ganglion Cells in Preclinical Glaucoma Models

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Animal Welfare in Surgery: Then and Now

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The Trainer's Toolkit for Osmotic Pumps: Supporting Researchers in Infusion Studies

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Leveraging Genomic, Preclinical, and Drug Response Data in the Age of AI

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High-Resolution Intravital In Vivo Imaging with AI-Powered Image Denoising

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Iconeus One: Pioneering Real-Time Whole-Brain Imaging with Functional Ultrasound - 14 Years of Innovation and Adoption

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Exciting Expansion in Preclinical Photoacoustic Imaging with VisualSonics Technology

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Aging and Injured Retinal Ganglion Cells can be Rejuvenated by Epigenetic Reprogramming

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Hypertension and Hypothalamic Changes in a Mouse Model of Menopause

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New Treatments for Vasomotor Symptoms Due to Menopause

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Hormonal and Chromosomal Influences on Autoimmunity and Lupus

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Migraine: Past, Present, and Future

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Polycystic Ovarian Syndrome and Cardiovascular Disease

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The Impact of Lateral Inhibition on Healthy Vision and Retinal Degeneration

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Pathophysiology of Endometriosis: Current Concepts and Clinical Translations

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Revolutionizing Fibrosis Imaging: Unveiling Shear Wave Elastography for Small Animal Imaging

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Non-Invasive Blood Pressure Measurement in Rodents: Considerations & Best Practices

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Preeclampsia: From Hippocrates to Contemporary Research

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Indirect Calorimetry for Rodent Research: New Approaches to Enhance Translational Value

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Sympathetic Regulation in Human Pregnancy

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Effects of Ovarian Failure on Muscle Form and Function

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Mimicking the Ventricular Pressure-Volume Relationship Ex Vivo with Cardiac Slices

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Deconstructing the Effects of Dietary Fat on Intestinal Cellular Networks

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Metabolic Mechanisms that Contribute to Pregnancy-Induced Cardiac Growth and its Reversal

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Clambake: An Algorithm to Decode Energy Expenditure Data from Metabolic Cages

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Genetic and Hormonal Components of Sex Differences in Alzheimer's Disease

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Visual Function with Aging in Normal and Alzheimer's Disease Model Mice

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Getting to the Heart of Cardiovascular Research: From Yesterday to Today and Looking Towards Tomorrow

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Applications of Humanized Mice in the Evaluation of Antibody-Drug Conjugates to Treat Autoimmune Diseases

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Molecular Signals Mediating Increases in Muscle Size and Function

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Photoacoustic Imaging in Angiotensin II Induced Cardiac Hypertrophy Mice

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Preclinical Animal Models of IBD, GVHD, and Pulmonary Disease

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Spatiotemporal Dynamics of Calcium and Neurotransmitters in Awake Mouse Models of Epilepsy

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Functional Ultrasound Neuroimaging: Principles, Applications, & Perspectives

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Unraveling European Animal Welfare Legislation for Biotech & Pharma

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Next-Generation Safety Assessment Tools for Advancing In Vivo to In Vitro Translation

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Superpixel Unmixing Algorithm from Micro to Macro Photoacoustic Imaging of Tissue Components

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Understanding Animal Welfare Best Practices in Asia Pacific for Biotech & Pharma

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Updates in Chronic Traumatic Encephalopathy (CTE)

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Combined Near Infrared Photoacoustic Imaging and Ultrasound Detects Vulnerable Atherosclerotic Plaque

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Developing a Novel Gene Therapy for Kcnv2 Retinopathy

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Navigating Animal Welfare Legislation in North America: Insights for Biotech & Pharma

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Compensatory Mechanisms in Parkinson's Disease

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Calcium Signaling in Neurons and Glia in the Mouse Brain During Exploratory Behavior

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Indwelling Portal Vascular Access Ports: Application, Advantages, and Management

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Measuring Neuronal Activity and Vascular Physiology in the Human Brain Using High-Resolution Functional Magnetic Resonance Imaging

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Advancing Disease Modeling for Drug Discovery by Modulating iPSCs with CRISPR and Neuronal Differentiation

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More Than What You Eat: The Regulation of Metabolic Health and Aging by Diet Composition and Activity

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Successful Modification of a Rodent Surgical Procedure and Device for Vascular Access in Minipigs (Vascular Access Button)

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Understanding Advanced Cardiac Tissue Slice Applications

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Control of Muscle Glucose Uptake in vivo: Thinking Outside the Myocyte

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Cellular Brain Repair for Parkinson's Disease: Is the Answer in the (Biomaterial) Matrix?

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Unveiling the Primate Brain: Advanced Insights through Ultra-Dense Electrophysiology

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Systemic and Intraspinal Pathology and Repair After Spinal Cord Injury in Rodents

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Monitoring Refractive Development in Mice to Investigate Mechanisms of Myopia

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From Models to Heartbeats: Computational Design of Vagus Nerve Stimulation for Cardiac Health

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Implantable Circuit-Specific Treatments for Autonomic Dysfunction

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Past, Present, and Future of the Columbus Instruments "CLAMS"

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Evaluation of Novel Therapies Using Spontaneous Seizure Models

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Cut and Paste of Myosin Binding Protein-C in Striated Muscles

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Turning Innovative Features Into Practical Benefits Within the Buxco Nose-Only Rodent Inhalation System

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Impact of Sleep and Circadian Disruption on Human Health and Disease Risk

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Integrating Patient Engagement and Trainee Development in Pre-Clinical Research

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New Horizons: Gonadotropin-Releasing Hormone and Cognition

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Exploring Estrogen's Role in Metabolism and the Use of 13C-Labeled Nutrients for Advanced Animal Physiology and Nutrition Research

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Talking Real Science with Stella Goulopoulou

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#ExpertAnswers: Andrew Gaffney and Erin Knock on Neural Progenitor Cell Differentiation

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Talking Real Science with Oliver Wearing

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#ExpertAnswers: Marcel Perret-Gentil on Improving Surgical Outcomes

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Talking Real Science with Martin Young

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#ExpertAnswers: Davide Boido and Antoine Bergel on Multimodal Neuroimaging

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#ExpertAnswers: Jastyn P√∂pplau and Marilena Hnida on Prefrontal Networks

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#ExpertAnswers: Artur Fedorowoski on Cardiovascular Dysautonomia in Post-COVID-19

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Talking Real Science with Yelena Akelina

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#ExpertAnswers: Connar Westgate on Intracranial Pressure Measurements

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#ExpertAnswers: Audrey Dubourg and Gareth Guenigault on the Organ-On-A-Chip Approach

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#ExpertAnswers: Sarah Greising on Muscle Injury Recovery

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#ExpertAnswers: Dudley Lamming on the Influence of Sex and Genetic Background on Diet

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#ExpertAnswers: Cole McLarty, Nick Glover, and Tim Hacker on Pressure-Volume Loops

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#ExpertAnswers: George Portugal on Microelectrode Array Technology

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#ExpertAnswers: Adrián Rodr√≠guez-Contreras and Barbara Lind on Neurovascular Coupling

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Industry Insights with Chris Rand from Aurora Scientific

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#ExpertAnswers: Aaron Phillips on Neural Hemodynamic Control

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#ExpertAnswers: Matthew Sparks on Vascular-Tubular Crosstalk

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Industry Insights with Amy Sheng on Nanobodies: An Important Tool for the Next Generation of Tumor Diagnostics and Therapeutics

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Industry Insights with Trent Lund on the ANY-maze Operant Interface

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Talking Real Science with Chris Perry

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#ExpertAnswers: Valeria Fumagalli and Nancy Kouassi on the Syrian golden hamster model of COVID-19

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#ExpertAnswers: Michael Long and Kari Hoffman on Electrophysiology

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#ExpertAnswers: Guto Montezano on COVID-19 and the Endothelium

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Industry Insights with Yuning Chen on Recombinant Proteins

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#ExpertAnswers: Jason Rogers and De Wet Wolmarans on Rodent Behavior Models

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#ExpertAnswers: Louise Parr-Brownlie and Conor Underwood on Optogenetic Stimulation

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Talking Real Science with Aaron Phillips

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#ExpertAnswers: Bin Xie on Drug Development for Immuno-Oncology

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#ExpertAnswers: Junseok Son on Maternal Exercise and Neonatal Health in Mice

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#ExpertAnswers: Danielle Senador and Cole McLarty on Biotelemetry

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#ExpertAnswers: Fiona McBryde on Blood Pressure and Flow

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#ExpertAnswers: Martin Young on Nutrient Intake Cycles and Metabolism

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#ExpertAnswers: Jason Gardner on Nicotine and the Heart

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#ExpertAnswers: Marc Reitman and Oksana Gavrilova on Thermal Physiology

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#ExpertAnswers: Andrea Bonetto on the Musculoskeletal Complications of Cancer and its Treatments

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#ExpertAnswers: Pierre Pouget and Serge Picaud on Functional Ultrasound Imaging

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#ExpertAnswers: Caroline Wuyts on Pregnancy and Glucose

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#ExpertAnswers: Joanna Hummer and Florie Le Prieult on cOFM for in vivo Cerebral Fluid Sampling

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#ExpertAnswers: Yasaman Soudagar and Roshni Christo on Neuronal Calcium Imaging

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#ExpertAnswers: Jonas Treebak and Alexander Bartelt on Metabolic Adaptations

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#ExpertAnswers: Paul Marvar on Fear and Cardiovascular Disease

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#ExpertAnswers: Stefano Gaburro and Brun Ulfhake on Aging Science

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#ExpertAnswers: Xuebin Qin on Inflammation and Immunophysiology

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#ExpertAnswers: Aileen King on Experimental Protocol

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#ExpertAnswers: Anna Cavaccini & James Dooley on Sensorimotor Network Development

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#ExpertAnswers: Rohan Jagirdar on Sleep and Alzheimer's Disease

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#ExpertAnswers: Fiona Harrison on Early Alzheimer's Disease

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#ExpertAnswers: Alexandra Lubin & Jason Otterstrom on Automated Microscopy

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#ExpertAnswers: P Boon Lim and Melanie Dani on Autonomic Dysfunction in Long-COVID

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#ExpertAnswers: Dudley Lamming on Aging Science

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#ExpertAnswers: Christian Schnell on Pharmacology Studies in Oncology Research

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#ExpertAnswers: Rizwan Qaisar & Matthew Borkowski on Aging Science

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#ExpertAnswers: Barry Setlow on Substance Use and Decision Making

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#ExpertAnswers: Andrea Benucci on Decision Making Behavior in Mice

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#ExpertAnswers: Angel Moreno on Optogenetics and the Cardiac Autonomic System

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#ExpertAnswers: Christopher Axelrod & Sander Kooijman on Rodent Models of Pharmacotherapy and Chronotherapy

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#ExpertAnswers: Michael Czech on CRISPR-Enhanced Adipocyte Browning

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#ExpertAnswers: Gilles Martin on Cellular Mechanisms Behind Alcohol Abuse and Binge Drinking Behavior

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#ExpertAnswers: Thao Nguyen on In-Vivo Cardiac Electrophysiology

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#ExpertAnswers: John Hasenau & Jeffrey Zynda on Animal Model Translation, Welfare and Housing

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#ExpertAnswers: Lais Berro on the Behavioral Effects of Benzodiazepines

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#ExpertAnswers: Alicia Brantley on Novel Object Tests

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#ExpertAnswers: Brendan Dougherty on Sex Hormones and Neuroplasticity

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#ExpertAnswers: Dee Silverthorn on Teaching Anatomy & Physiology

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#ExpertAnswers: Julio Ayala & Matt Robinson on Stress, Exercise, Metabolism and Obesity

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#ExpertAnswers: Scott Hall on Attention Deficit Hyperactivity Disorder (ADHD)

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#ExpertAnswers: Simon Schultz & Michael Goard on Two-Photon Neuroimaging

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#ExpertAnswers: Corina Bondi on Traumatic Brain Injury

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#ExpertAnswers: Lauren Woodie and Matt Morris on Metabolism, Diet, & Energy Expenditure

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#ExpertAnswers: Lior Bikovski & Shivang Sunil Parikh on Home Cage Monitoring Systems for Behavioral Research

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#ExpertAnswers: Ricci Wesselink on Nursing Education

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#ExpertAnswers: Robert Wykes & Anthony Umpierre on Studying Epilepsy Using Microscopy, Electrophysiology, and Optogenetics

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#ExpertAnswers: Fred Beasley on Obesity

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#ExpertAnswers: Sharon Ladyman & Vicki Vieira-Potter on Metabolic Phenotyping

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#ExpertAnswers: Carl Petersen & Alexei Verkhratsky on Functional Neuroimaging

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#ExpertAnswers: Katsu Funai on Obesity

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#ExpertAnswers: Zhen Yan & Diego Bohórquez on Obesity

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#ExpertAnswers: Chris Ward, Ramzi Khairallah & Sharon Hesterlee on Muscular Dystrophy

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#ExpertAnswers: Artem Shatillo & Zsolt Lenkei on Functional Ultrasound Imaging

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#ExpertAnswers: Ole Petersen, Roop Mallik & Erwin Neher on Endocytosis and Calcium Signaling in the Context of SARS-CoV-2

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#ExpertAnswers: Marshall McCue on Stable Isotope Tracers in Preclinical Models of Obesity

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#ExpertAnswers: Jennifer Petrosino & Chris Adams on VO2 Max

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#ExpertAnswers: John Hasenau and Stefano Gaburro on Biosafety in Animal Modeling

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#ExpertAnswers: DeWayne Townsend and Adam Goodwill on the Fundamentals of Pressure-Volume Loop Analysis

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#ExpertAnswers: Miroslaw Janowski and Piotr Walczak on Imaging for Precision Medicine

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#ExpertAnswers: Kaushikaram Subramanian & Volker Enzmann on the Optomotor Reflex

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#ExpertAnswers: Tonya Coulthard on the Capabilities of PET/CT Imaging

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#ExpertAnswers: Tim West & Matt Borkowski on Single Muscle Fiber Mechanics

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#ExpertAnswers: Robert Gould and Michael Girand on Utilizing EEG to Study Sleep, Substance Use and CNS Disorders

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#ExpertAnswers: John Cirrito & Candace Rhode-Johnson on Micro-dialysis and Neuroscience

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#ExpertAnswers: Konrad Juczewski and Mary Ann Go on Place Cell Mapping and Stress Monitoring

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#ExpertAnswers: Ralph Lydic and Tally Largent-Milnes on the Opioid Epidemic

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#ExpertAnswers: Melanie White on Isolated Langendorff Heart Principles

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#ExpertAnswers: Sarah Stuart, Jon Pacios-Filardo, Alexander Dityatev, Weilun Sun, and Norbert Hájos on Neurophysiology

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#ExpertAnswers: Marcio Furtado on EEG Monitoring in the Study of Experimental Epilepsy

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#ExpertAnswers: Tim Hacker on Models of Cardiovascular Disease in Rodents

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#ExpertAnswers: Keshari Thakali and Aaron Stupica on Maternal Obesity Effects on Offspring

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#ExpertAnswers: Clive May and Yugeesh Lankadeva on Measuring Tissue Perfusion

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