Getting Started with In-Vitro Blood Vessel Research

Date:

February 24, 2015

Dr. Scott Earley and Dr. Gerry Herrera review essential tools and techniques for studying function in isolated blood vessels using a pressurized arteriograph system.

During this webinar sponsored by Living Systems Instrumentation, presenters review dissection and mounting techniques, equipment requirements, proper experimental design, and discuss the difference between pressurized cannulation systems and wire myograph/tissue bath systems.

Dr. Scott Earley shares strategies for skills development, in particular starting research with 2nd order mesenteric artery samples and how to generate vessel constrictions and dilations. In addition, he discusses an advanced application involving the assessment of myogenic reactivity in a "blind-sac" vessel preparation using a cerebral parenchymal arteriole.

専門家の見解：

Scott Earley

PhD

University of Nevada School of Medicine

Associate Professor of Pharmacology

Gerry Herrera

PhD

Catamount Research & Development Inc.

President

スポンサー：

Living Systems Instrumentation

コンテンツを探す

Living Systems Instrumentation is the leading supplier for your vascular research needs, including pressure arteriograph and wire myograph systems.

https://www.livingsys.com

トピック

Disease Models

Pharmacology

Getting Started with In-Vitro Blood Vessel Research

専門家の見解：

Scott Earley

PhD

Gerry Herrera

PhD

スポンサー：

Living Systems Instrumentation

トピック

関連コンテンツ

Advancing Metabolic Disease Drug Development: Translational Models and a GLP-1 Receptor Agonist Metabolism Case Study

Improving Translational Decision-Making through Disease-Relevant Preclinical Models in Pulmonary Fibrosis and Pain Drug Discovery

Smarter Drug Discovery: Turning Screening Hits into Opportunities

Smarter Drug Discovery: Turning Screening Hits into Opportunities

Improving Translational Decision-Making through Disease-Relevant Preclinical Models in Pulmonary Fibrosis and Pain Drug Discovery

Advancing Metabolic Disease Drug Development: Translational Models and a GLP-1 Receptor Agonist Metabolism Case Study

Building New Approach Methodologies (NAMs) and Complex In Vitro Assays

From Skull to Deep Brain: Exploring Brain Dynamics with Intravital Imaging

A More Complete Picture of Antibody Function: Lessons from Comprehensive Fc Profiling of Approved Anti-CD20 Antibodies

Advancing Skin Research: A Scalable 3D Human Skin Organoid Model for Skin Barrier Function and Injury Screening

AI-Ready, Lab-Proven: A New Standard for High-Throughput Antibody Characterization

Enhancing Clinical Predictability through Human Disease-relevant Preclinical Models in CNS and Muscle Drug Discovery

Visualizing Lipid Control of Drug Binding in Membrane Proteins at High Resolution

Structure is Strategy: Integrating Cryo‑EM, X‑ray, NMR and HDX‑MS for Precision Drug Discovery

New Approach Methodologies (NAMs): Key Considerations and Applications

From Clinical Data to Actionable Assets for Pharmaceutical R&D

Strategies to Optimize Commercialization of Oncology Treatments for Younger Adults

Patient Data: Opportunities for Rare Diseases, Cell and Gene Therapies, and Oncology

Trials and tribulations of drug development

Webinar Series: Early patient preferences for patient-focused drug development

Using AI and Technology to Streamline Post-Stroke Patient Journeys to Cardiology

Looking Beyond Survival Data: Understanding the Value of Non-OS Endpoints in Oncology Reimbursement Decision-Making

Cutting Edge Conversations: Fighting Neurodegenerative Diseases

Cutting Edge Conversations: Discovering New Innovations in Oncology

Cutting Edge Conversations: Addressing COVID-19 During Uncertainty

Cutting Edge Conversations: Finding Solutions to the Obesity Epidemic

Functional Ultrasound Demonstration and Live Q&A: Iconeus One, a Pioneer in Real-Time Whole-Brain Imaging

Detecting Early Synaptic Failure in Prion Disease Using Organoid Models

Improving Preclinical Decision-Making in Obesity and CKD with Translational In Vivo Phenotyping

Advancing the Manufacture of Mesenchymal Stromal Cells and Derived Extracellular Vesicles in Stirred-Tank Bioreactors Through Enhanced Bioprocess Control

How to Avoid Expensive Redesign Cycles in Antibody Discovery

From Genetic Validation to Relevant Target Engagement: Small Molecule Inhibitor Binding to 17β-HSD13

Bridging Mouse Models and Human Inflammatory Bowel Disease: in vivo Pharmacology, Histology and Biomarkers

Engineering Neuromodulation for Cardiovascular Instability

Skeletal Muscle Circadian Clocks: Keeping Time for Systemic Health

Improving Confidence in Thyroid Hormone Disruption Assessment Using a Novel Human-Relevant In Vitro Model

Accelerating Antibody Discovery: Integrating Microfluidics, HT Expression, and Early Developability Platform

Beyond Exposure: Integrating PK/PD for Translational Predictive Power

Screening the Unscreenable: Expanding the Reach of Drug Discovery

Illuminating the Brain: Advances in Neurobiology

Fulfilling the Gap: Innovative Critical Reagents for Non-Human Primate Preclinical Studies

Advancing ADC Development: Leveraging AI and Translational Preclinical Models to Improve Clinical Predictability

Human iPSC-Derived Sensory Neurons for Functional Sensory Biology and Pharmacology Research

From Biopsy to Better Decisions: Patient-Derived Organoids Predict Treatment Response in Metastatic Colorectal Cancer

Accelerating Conjugation Process Development for Next-Generation ADCs: Key Considerations and Platform Strategies

High-Throughput-qPCR and Transcriptomics: Powering the Next Generation of Drug Discovery

Epigenomics at 360 in Liquid Biopsy: Approaches and Case Studies for Biomarker Discovery and Drug Development

The Sound of Science: Mapping the Tumor Microenvironment for Advanced Therapeutic Strategies

Precision in Human Biological Samples: Leveraging Regulatory Rigor and Deep Data for Advanced Disease Research

Next-Generation TCR-Like Antibodies With Improved Specificity Profiles

ADC Payload-Linker CMC Process Development Strategy

Opening a New Window: Stable Long-Term Imaging of Dura Mater-Transplanted Pancreatic Islets in Awake Mice

De-Risking Immunotherapy Targets with Next-Gen HLA Discovery Platforms

The Expert Approach to Preclinical Indirect Calorimetry Experiments

Photoreceptor Cell Therapy to Treat Advanced Retinal Degeneration

Clinical Applications of Optical Cerebral Blood Flow Imaging

ADCs on The Horizon: The Performance and Prospect of Cell Line Development Platform AmigoCHO

Building New Approach Methodologies for Angiogenesis and Vascularized Models

Using ALS Patient-Derived Motor Neurons to Study TDP-43 Mislocalization

Gene-Agnostic Gene Therapy to Preserve Vision

Vevo Ask The Experts: Oncology Imaging

hiPSC-Cardiomyocyte Platforms Enabling Comprehensive Cardiac Toxicity and Drug Efficacy Evaluation

Transcranial Focused Ultrasound Neuromodulation of the Default Mode Network in the Treatment of Depression and Promotion of Wellness

Protein-Protein Interaction (PPI) Landscape - Sequence-to-Affinity Heatmaps for High-Throughput Antibody Optimization

Human Biological Samples in Research: Quality, Compliance, and Clinical Relevance

FUJIFILM VisualSonics' Advanced Cardio Symposium

Combination Therapy for Glioblastoma: A Personalized, AI-Driven Approach

In Vivo panCAR Therapy Using Circular RNA for the Treatment of Autoimmune Disease

Noninvasive Imaging of Liver Disease by MRI and Photoacoustic Ultrasound

Recent Advances in Diagnosis of Autonomic Syncope