Blood is drawn from donors at the company's own test site in Uppsala, so fresh, minimally manipulated whole blood reaches the assay quickly. The platform carries the name ID.Flow, and it keeps blood and test substance circulating continuously at a regulated 37 degrees Celsius, producing more than 40 readouts from every test condition. Those readouts take in cytokine release, ADCC and CDC studied simultaneously, the complement split products C3a, C5a and Bb, activation and depletion of B cells, T cells, NK cells, monocytes and granulocytes, and platelet counts, activation, conjugates and aggregation. Packages are offered for antibodies, antibody-drug conjugates and oligonucleotide therapeutics. Regulators now encourage New Approach Methodologies, and results are used as human-based weight of evidence in IND and IMPD submissions, and to prioritize candidates and set a safe starting dose.
Immuneed
Immuneed is a specialized biotechnology company offering a unique first-in-human simulation tool through its proprietary whole-blood loop assay system. Designed to evaluate the immunogenicity and acute immune responses of therapeutic antibodies and biologics prior to clinical trials, Immuneed provides invaluable data that de-risks development and ensures patient safety.
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