Proteros Biostructures

Proteros Biostructures is a world-class, structure-based drug discovery partner specializing in high-resolution X-ray crystallography, cryo-EM, and advanced biophysical analysis. By providing detailed insights into protein-ligand interactions and kinetics, Proteros enables rational drug design and lead optimization for challenging pharmaceutical targets.
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Founded on Nobel Prize winning science from the Max Planck Institute of Biochemistry, Proteros works from the Martinsried biotech cluster outside Munich, with North American offices in Cambridge, Massachusetts and San Diego. Its building assigns separate floors and lab suites to structural biology, cryo-EM, protein sciences, biologics, and assays, all under one roof. Attention goes to what the team calls high hanging fruits: multi-subunit complexes, membrane and membrane-associated proteins including GPCRs and ion channels, and constructs that must retain a physiologically relevant function. Cryo-EM projects move from protein preparation and feasibility analysis through condition optimization to low- and high-resolution structure determination, while crystallographic fragment screening and the Qualified Hits program carry targets toward chemistry. A gallery of proteins, structures, and assays is searchable by variant and UniProt ID, and more than 200 pharma and biotech partners across the US, Europe, and Japan have used the group.