Work is split across three classes of preparation. Langendorff isolated perfused hearts strip out the autonomic, vascular, and metabolite influences that can mask a test article's direct cardiac effects, quantifying coronary vascular resistance and resolving QT and QT instability to millisecond accuracy. In vivo studies use conscious, telemetered, or anesthetized animals to read inotropy, lusitropy, baroreceptor function, and reperfusion arrhythmias, with intra-coronary dosing available. Disease models permissive to torsade de pointes reproduce heart failure, arrhythmia, ischemia, hypertension, and diabetes rather than healthy physiology. All of it is GLP compliant and runs at the laboratory in Columbus, Ohio.
QTest Labs
QTest Labs is a CRO that specializes in efficacy, cardiovascular safety, and risk assessment of a pharmaceutical or medical device.
Our aim is to minimize lead-time and cardiovascular risk, while increasing mechanistic understanding of the test article or device.
