Dr. Bradley Palmer demonstrates the challenging preparation of cardiac tissue slices and measurement of force and calcium.
Unlike isolated cardiomyocytes, cardiac tissue slices better preserve the native myocardial tissue, including both fibroblasts and myocytes. And unlike whole heart studies, slices are better suited for acquisition of functional parameters like calcium transients. Unlike both models, however, cardiac slices have not been widely utilized and their preparation remains a significant challenge for many labs. In this webinar, Dr. Bradley Palmer shows how to successfully prepare cardiac slices for measurements of force and calcium, as well as work loops and stress and strain. Data analysis and interpretation are also demonstrated.
Presenters
Bradley Palmer
Dr. Bradley Palmer's interests have focused on bringing engineering principles to combat heart failure. His most recent work has focused on using cardiac slices mimicking the Pressure-Volume relationship to detect and discern the molecular mechanisms responsible for cardiac function observed with pathological states like heart failure, diabetes, and hypertension.
Sponsor
IonOptix
Content Partners
American Physiological Society
About APS
Mission: To advance scientific discovery, understand life, and improve health. Vision: A global multidisciplinary community of scientists solving the major problems affecting life and health. Founded in 1887, the American Physiological Society is a global leader in expanding knowledge related to biological function. We connect a multidisciplinary community of nearly 10,000 scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. Our members are advancing treatments and cures for everything from cancer and heart disease, to obesity and addiction. They are also deepening our insight into living organisms generally, helping us to better understand how things like climate change are affecting the world around us. The Society serves this dynamic community in many ways, including:- Publishing 16 globally recognized scholarly journals and a highly-regarded book monograph series;
- Sponsoring scientific meetings and symposia that explore the frontiers of bio-medical science;
- Advocating for science-smart public policy that benefits both our members and the public;
- Bestowing hundreds of awards, grants, and fellowships that recognize scientific excellence and promise;
- Championing physiology education and educators, to support bigger discoveries and better clinical outcomes;
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European Council for Cardiovascular Research
The history of the European Council for Cardiovascular Research (ECCR) goes back more than 30 years when the ‘European Blood Pressure Group’ held its first meeting in March 1979 in Cambridge, UK. To date more than 30 international meetings have been held in various European locations. For more information about ECCR history click here.
The mission of ECCR is to promote prevention, diagnosis and treatment of disease and the preservation and protection of good health through experimental and clinical research in hypertension, cardiovascular and metabolic disease.
ECCR holds an Annual Meeting in October. The purpose of these scientific meetings is to provide a forum for active clinical and non-clinical researchers to discuss important aspects of their work, to advance and strengthen European research in the field of cardiovascular disease, high blood pressure and cardiometabolic disease. The meetings bring together both senior and junior scientists from the leading European groups in the field of cardiovascular research.
ECCR is a member of the Council for Basic Cardiovascular Science (CBCS) of the European Society of Cardiology (ESC), whose aims are to enhance the importance of basic science to clinical cardiology and act as a Europe wide forum for cardiovascular research societies, and a conduit for positive collaboration.
