Endothelial Caspase-9 Mediates Inflammatory and Vision Function Changes in Retinal Vascular Injury

Sponsored by:

Date:

July 20, 2022

Time (PT):

10:00 AM

Duration (min):

No items found.

Watch now as Crystal Col√≥n Ortiz, PhD, from the Columbia University Medical Center discusses the inflammatory role of endothelial caspase-9 in neurovascular injury and its contribution to vision changes.

Retinal vein occlusion (RVO) induces pathological consequences including retinal edema, capillary ischemia, and neurodegeneration. In a mouse model of RVO, non-apoptotic expression of endothelial caspase-9 (EC Casp9) can be observed. Knockout of EC Casp9 leads to a decrease in RVO-induced pathology.

In this presentation, Crystal Col√≥n Ortiz describes this mouse model of RVO and discusses known roles of caspases and glial cells in the retina and during vascular injury. Crystal also presents a recent study that reveals that at early time-points post-RVO, EC Casp9 mediates glial changes and promotes high levels of pro-inflammatory cytokines. Behaviorally, this results in contrast sensitivity decline in these animals.

Who Should Attend?

Researchers interested in neuroimmunological disorders, vision science and measuring visual acuity, demyelinating diseases, and aging.

Presenters

Crystal Colón Ortiz

Columbia University Medical Center

Graduate Student

Crystal recently defended her PhD thesis in the lab of Dr. Carol Troy at Columbia University Irving Medical Center. During her graduate trajectory, she was awarded with NSF-Graduate Research Fellowship Program, the Association for the American Advancement of Science (AAAS) Program for Excellence in Science, the Society for Neuroscience (SfN) Trainee Professional Development Award, and the NIH Blueprint Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) Award.

Striatech

Striatech is a young biotech company that spun off from the University of Tübingen, Germany, at the beginning of 2018. The founders – a team of neurobiologists – are all experienced vision researchers and have made it their common goal to make innovative ideas and products from vision and behavioral research accessible to scientists worldwide.

Topics

Disease Models

Endothelial Caspase-9 Mediates Inflammatory and Vision Function Changes in Retinal Vascular Injury

Who Should Attend?

Presenters

Crystal Colón Ortiz

Sponsor

Striatech

Topics

Watch Now

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