In Vivo Modeling of Immune-mediated Optic Neuropathies

Sponsored by:

Date:

November 9, 2022

Time (PT):

10:00 AM

Duration (min):

No items found.

Oliver W. Gramlich, PhD, provides an in-depth discussion about the pathobiology and visual phenotype of immune-mediated optic neuropathies.

Multiple sclerosis (MS), neuromylitis optica spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) all feature distinct clinicopathologic phenotypes. These phenotypes will be highlighted in relevant preclinical models of optic neuritis by utilizing highly translational functional and structural measurements of vision.

The webinar features an introduction of relevant animal models, and explains pertinent experimental techniques ranging from behavioral assessment of visual acuity (VA) with the OptoDrum, to electrophysiology recordings via pattern electroretinography (pERG) and visual evoked potential (VEP) recordings, to structural imaging of the retina with optical coherence tomography (OCT).

Who Should Attend?

Researchers working in the field of vision science, multiple sclerosis-related optic neuritis and glaucoma, neuroimmunology,¬†and neuroinflammation.

Presenters

Oliver W. Gramlich

The University of Iowa (Ophthalmology and Visual Sciences)

Research Assistant Professor

Oliver Gramlich studied Biology and Neurobiology at the University of Mainz followed by a PhD focusing on Experimental Ophthalmology. He then started a position at the University of Iowa where he is now working as Research Assistant Professor at the Department of Ophthalmology and Visual Sciences. Besides his research efforts on Multiple Sclerosis-related optic neuritis and glaucoma, he is currently establishing a model of Neuromyelitis optica in order to help establish reliable preclinical models that faithfully reproduce visual impairment as seen in patients.

Striatech

Striatech is a young biotech company that spun off from the University of Tübingen, Germany, at the beginning of 2018. The founders – a team of neurobiologists – are all experienced vision researchers and have made it their common goal to make innovative ideas and products from vision and behavioral research accessible to scientists worldwide.

Topics

Disease Models

In Vivo Modeling of Immune-mediated Optic Neuropathies

Who Should Attend?

Presenters

Oliver W. Gramlich

Sponsor

Striatech

Topics

Watch Now

Related Content

Engineering Neuromodulation for Cardiovascular Instability

Improving Preclinical Decision-Making in Obesity and CKD with Translational In Vivo Phenotyping

Detecting Early Synaptic Failure in Prion Disease Using Organoid Models

Functional Ultrasound Demonstration and Live Q&A: Iconeus One, a Pioneer in Real-Time Whole-Brain Imaging

Precision in Human Biological Samples: Leveraging Regulatory Rigor and Deep Data for Advanced Disease Research

Detecting Early Synaptic Failure in Prion Disease Using Organoid Models

Improving Preclinical Decision-Making in Obesity and CKD with Translational In Vivo Phenotyping

Bridging Mouse Models and Human Inflammatory Bowel Disease: in vivo Pharmacology, Histology and Biomarkers

Skeletal Muscle Circadian Clocks: Keeping Time for Systemic Health

Using AI and Technology to Streamline Post-Stroke Patient Journeys to Cardiology

Cutting Edge Conversations: Fighting Neurodegenerative Diseases

Cutting Edge Conversations: Addressing COVID-19 During Uncertainty

Cutting Edge Conversations: Finding Solutions to the Obesity Epidemic

Engineering Neuromodulation for Cardiovascular Instability

Illuminating the Brain: Advances in Neurobiology

Fulfilling the Gap: Innovative Critical Reagents for Non-Human Primate Preclinical Studies

Advancing ADC Development: Leveraging AI and Translational Preclinical Models to Improve Clinical Predictability

Opening a New Window: Stable Long-Term Imaging of Dura Mater-Transplanted Pancreatic Islets in Awake Mice

The Expert Approach to Preclinical Indirect Calorimetry Experiments

Photoreceptor Cell Therapy to Treat Advanced Retinal Degeneration

Clinical Applications of Optical Cerebral Blood Flow Imaging

Using ALS Patient-Derived Motor Neurons to Study TDP-43 Mislocalization

Gene-Agnostic Gene Therapy to Preserve Vision

Vevo Ask The Experts: Oncology Imaging

hiPSC-Cardiomyocyte Platforms Enabling Comprehensive Cardiac Toxicity and Drug Efficacy Evaluation

Transcranial Focused Ultrasound Neuromodulation of the Default Mode Network in the Treatment of Depression and Promotion of Wellness

FUJIFILM VisualSonics' Advanced Cardio Symposium

In Vivo panCAR Therapy Using Circular RNA for the Treatment of Autoimmune Disease

Noninvasive Imaging of Liver Disease by MRI and Photoacoustic Ultrasound

Recent Advances in Diagnosis of Autonomic Syncope

Uniting biology and digital drug discovery to identify new therapeutic opportunities in neurodegeneration

Reprogramming Mouse Fibroblasts Into Induced Cardiomyocytes: Age-Related, Metabolic, and Epigenetic Barriers

Exploring the iPSC-Derived Neuronal-Glia Co-culture System: A Powerful Drug Discovery Platform for Studying Neurodegenerative Diseases

Redox Regulation of Skeletal Muscle: A Journey from Liverpool to the International Space Station

Advances in Preclinical Research using Human Co-culture Models: Applications in Immunology, Infectious Disease, and Oncology

RIP1 Inhibition Protects Retinal Ganglion Cells in Preclinical Glaucoma Models

The Trainer's Toolkit for Osmotic Pumps: Supporting Researchers in Infusion Studies

High-Resolution Intravital In Vivo Imaging with AI-Powered Image Denoising

Leveraging Genomic, Preclinical, and Drug Response Data in the Age of AI

Animal Welfare in Surgery: Then and Now

Iconeus One: Pioneering Real-Time Whole-Brain Imaging with Functional Ultrasound - 14 Years of Innovation and Adoption

Exciting Expansion in Preclinical Photoacoustic Imaging with VisualSonics Technology

Aging and Injured Retinal Ganglion Cells can be Rejuvenated by Epigenetic Reprogramming

Hypertension and Hypothalamic Changes in a Mouse Model of Menopause

Migraine: Past, Present, and Future

The Impact of Lateral Inhibition on Healthy Vision and Retinal Degeneration

An Advancement in Pressure-Volume Technology: Meet the Millar MPVS Duo

Revolutionizing Fibrosis Imaging: Unveiling Shear Wave Elastography for Small Animal Imaging

Non-Invasive Blood Pressure Measurement in Rodents: Considerations & Best Practices

Indirect Calorimetry for Rodent Research: New Approaches to Enhance Translational Value

Mimicking the Ventricular Pressure-Volume Relationship Ex Vivo with Cardiac Slices

Deconstructing the Effects of Dietary Fat on Intestinal Cellular Networks

From Biological Exploration to Clinical Translation: Lipoproteins in Inflammation Response

New Treatments for Vasomotor Symptoms Due to Menopause

Warming Up for Success: Comparative Efficacy of Thermoregulatory Devices in Rodent Anesthesia

Best Practices: Measuring Force, Resting Sarcomere Length, and Calcium in Cardiac Slice Preparations

Effects of Ovarian Failure on Muscle Form and Function

Sympathetic Regulation in Human Pregnancy

Preeclampsia: From Hippocrates to Contemporary Research

Polycystic Ovarian Syndrome and Cardiovascular Disease

Genetic and Hormonal Components of Sex Differences in Alzheimer's Disease

Metabolic Mechanisms that Contribute to Pregnancy-Induced Cardiac Growth and its Reversal

Visual Function with Aging in Normal and Alzheimer's Disease Model Mice

Cardiac Trabeculae Dissection and Experiments with the Aurora Scientific 1500A

Applications of Humanized Mice in the Evaluation of Antibody-Drug Conjugates to Treat Autoimmune Diseases

Getting to the Heart of Cardiovascular Research: From Yesterday to Today and Looking Towards Tomorrow

Molecular Signals Mediating Increases in Muscle Size and Function

Let's Get Physiological: Non-Invasive Intraoperative Monitoring Basics

Preclinical Animal Models of IBD, GVHD, and Pulmonary Disease

Photoacoustic Imaging in Angiotensin II Induced Cardiac Hypertrophy Mice

Spatiotemporal Dynamics of Calcium and Neurotransmitters in Awake Mouse Models of Epilepsy