Watch Dr. Ana Briones present her research on the effects and potential therapeutic targets of excessive inflammation and vascular damage in hypertension.
Inflammation is a typical feature of many cardiovascular diseases such as atherosclerosis, aneurysms, obesity, or hypertension. In hypertension, excessive inflammation from innate and adaptative immune systems associated with elevated levels of local and circulating proinflammatory cytokines and oxidative stress, plays a key role in endothelial dysfunction, vascular remodeling, and augmented vascular stiffness associated to this pathology.
Excessive inflammation can result from elevated cytokines production, but unresolved or inefficient resolution of inflammation might also contribute to the augmented inflammatory milieu found in the vasculature of different cardiovascular diseases. Resolution of inflammation is mediated by a family of specialized pro-resolving mediators (lipoxins, resolvins, protectins, maresins), that limit immune cell infiltration and initiate tissue repair mechanisms.
Dr. Briones shows the latest advances on the role of novel proinflammatory mediators associated to vascular damage in hypertension. Moreover, she discusses the potential beneficial effects of boosting resolution of inflammation as a new therapeutic approach for the treatment of hypertension and vascular alterations.
Presenters
Ana Briones
Ana Briones is Associate Professor at the Pharmacology Department in the Universidad Autónoma de Madrid (Spain). Her lab is focused on the role of inflammation and resolution of inflammation in the cardiovascular damage associated to hypertension, obesity, and aneurysms.
Sponsor
Kent Scientific Corporation
Content Partners
American Physiological Society
About APS
Mission: To advance scientific discovery, understand life, and improve health. Vision: A global multidisciplinary community of scientists solving the major problems affecting life and health. Founded in 1887, the American Physiological Society is a global leader in expanding knowledge related to biological function. We connect a multidisciplinary community of nearly 10,000 scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. Our members are advancing treatments and cures for everything from cancer and heart disease, to obesity and addiction. They are also deepening our insight into living organisms generally, helping us to better understand how things like climate change are affecting the world around us. The Society serves this dynamic community in many ways, including:- Publishing 16 globally recognized scholarly journals and a highly-regarded book monograph series;
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European Council for Cardiovascular Research
The history of the European Council for Cardiovascular Research (ECCR) goes back more than 30 years when the ‘European Blood Pressure Group’ held its first meeting in March 1979 in Cambridge, UK. To date more than 30 international meetings have been held in various European locations. For more information about ECCR history click here.
The mission of ECCR is to promote prevention, diagnosis and treatment of disease and the preservation and protection of good health through experimental and clinical research in hypertension, cardiovascular and metabolic disease.
ECCR holds an Annual Meeting in October. The purpose of these scientific meetings is to provide a forum for active clinical and non-clinical researchers to discuss important aspects of their work, to advance and strengthen European research in the field of cardiovascular disease, high blood pressure and cardiometabolic disease. The meetings bring together both senior and junior scientists from the leading European groups in the field of cardiovascular research.
ECCR is a member of the Council for Basic Cardiovascular Science (CBCS) of the European Society of Cardiology (ESC), whose aims are to enhance the importance of basic science to clinical cardiology and act as a Europe wide forum for cardiovascular research societies, and a conduit for positive collaboration.
