The objective of this webinar is to provide perspective on the current in vitro permeation testing (IVPT) landscape and to demonstrate how scientific rigor and creative problem-solving can address diverse industry needs when developing and evaluating dermatological products or products with potential for dermal exposure.
As complex topical products (e.g., transdermal patches and biologics), novel cosmetic ingredients, and new agrochemicals emerge, in vitro permeation testing (IVPT) has become a powerful tool spanning early discovery through preclinical and regulatory studies. Its growing adoption across industries has been further driven by global efforts to refine, reduce, and replace animal use (the 3Rs) in preclinical testing and beyond. Continuing to expand our understanding of IVPT guidance and how novel topical products and exposure scenarios can be evaluated within existing frameworks is critical.
Key Topics:
- An overview of the global guidance documents that outline requirements for successful IVPT studies.
- Trends in the application of IVPT to risk assessment, including on how going beyond current guidance can be beneficial as the complexity and novelty of topical products continues to increase.
- Strategies for adapting traditional IVPT approaches to meet evolving industry demands: including lessons learned from incorporating external stimuli, defining excised skin requirements, and strengthening IVPT conclusions through the integration of mechanistic skin modeling.
Featuring Insights from
Lauren Brown
,
MS, DABT
Lauren Brown is a board certified toxicologist with more than 15 years of experience supporting consumer product, cosmetic, and environmental health decision making through rigorous, evidence based science. Her consulting approach is grounded in a commitment to public health protection and the clear, defensible interpretation of complex data.
Trained at the Harvard T.H. Chan School of Public Health and experienced across government, NGOs, start ups, and Fortune 500 companies, Lauren specializes in toxicological risk assessment, ingredient and product safety evaluations, next generation risk assessment, systematic literature reviews, and the development of toxicological reference values. She has led assessments for a wide range of chemical ingredients and exposure scenarios, integrating diverse evidence streams to deliver transparent, actionable conclusions.
Before founding Applied Risk and Toxicology, Lauren served in senior scientific roles at highly respected consulting firms, where she conducted and directed risk assessments for consumer products, cosmetics, OTC ingredients, and drinking water contaminants.
Alec Salminen
,
PhD
Alec Salminen, PhD is Manager of the In Vitro Assay Services group at LifeNet Health LifeSciences, leading a team that provides comprehensive in vitro toxicology testing to industry, government, and academic partners.
Sponsored by
LifeNet Health LifeSciences
In Partnership with
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