In this webinar, experts explore how high-quality biospecimens, longitudinal data, and regulatory rigor drive the future of biomarker discovery and clinical diagnostics.
The Critical Role of Specimen Quality, Longitudinality & Data Depth: An Alzheimer's Use Case Example
Cathie Miller, PhDSenior Director of Product Management, BioIVT
Accurate research relies on the quality and relevance of biospecimens that are utilized. Using Alzheimer's disease (AD) as an example, Dr. Miller will discuss how a foundation of high-quality, rigorously characterized biospecimens are building the future of AD diagnostics.
The current AD diagnostic revolution relies on accessible blood-based biomarkers like pTau217 and pTau181 to bridge the global detection gap. However, valid clinical implementation demands more than just new assays. Success hinges on three pillars: pre-analytical rigor to ensure biomarker stability, longitudinal tracking to map disease progression, and comprehensive metadata to address health disparities.
Progress can be accelerated by integrating matched plasma-CSF sets and multi-timepoint collections that track donors over years. Furthermore, ethnically diverse cohorts and strictly controlled raw materials enable researchers to harmonize assays, validate clinical cutoffs, and ensure diagnostics work for all populations. These specialized resources provide the essential infrastructure to transform promising biomarkers into widely available diagnostic tools.
Sample Expertise at the Service of Research Projects: Scientific Consistency, Regulatory Rigor, and Analytical Performance
Pauline Mespoulhé, MScBiobank Manager, France Tissue Bank
Research success hinges on more than a strong hypothesis; it requires precise alignment between your scientific objective and specimen selection long before analysis begins. This webinar explores how to optimize outcomes by matching sample types, from FFPE blocks to digital images, with their ideal applications, while navigating the "expertise ecosystem" of ISO 15189 standards, regulatory compliance, and longitudinal data integration. Through practical AI and biomarker case studies, we demonstrate that a high-quality sample is not just biological material, but the essential scientific, regulatory, and strategic foundation of your entire project.
Presenters
Cathie G. Miller
With a career that spans over 20 years at the bench, as well as a Director and a Global Product Manager, all involving the use of biospecimens in the fields of cancer, immunology and virology, Cathie is now Senior Director of Product Marketing, Personalized Medicine, at BioIVT.
Pauline Mespoulhé
Pauline Mespoulhé is a biobank and health data expert specializing in the valorization of human biological samples and their integration into innovative research projects. She supports biotech, pharma, medtech, and academic teams in ensuring scientific, regulatory, and strategic alignment to strengthen project quality and impact.
Sponsor
BioIVT
France Tissue Bank
Content Partners
Scientist.com
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