Webinar Summary
- Understand the challenges and limitations of traditional blood sampling and infusion methods in Göttingen Minipigs
- Explore the advantages and adaptability of the Rat Vascular Access Button for efficient blood sampling and dosing
- Strategies for thinking outside the box to enhance experimental design in animal studies
Infusion and serial blood sampling are often important technical aspects of an experimental design. Superficial vessels in the minipig are few and frequently accessing them is a challenge. Although minipigs have a convenient size for handling, restraint and venipuncture can be stressful and affect blood parameters. Therefore, when experiments require infusion or frequent blood sampling, catheterization is often the best option, both ethically and scientifically.
The implantation of Vascular Access ports and Seldinger Catheters is described and published in various variations. To add another option when choosing the optimal study design, the Rat Vascular Access Button in Göttingen Minipigs was tested. The port allows up to four catheters to be connected and opens the possibility to sample and dose via one port but through different catheters. Adrian did several preliminary studies before the system had matured to be used in proper pharmacokinetic studies. Based on feedback from these studies, the implantation procedure has been continuously refined and improved. This has resulted in more than 200 Göttingen Minipigs that have been successfully implanted with Vascular Access Buttons.
Presenters
Adrian Zeltner
Adrian Zeltner is president elect of EALAS, the European Academy of Laboratory Surgery and is a member of the ARS, the Academy of Surgical Research (USA). Since September 2023 he works full time for his company AZE Consulting. Adrian was senior surgeon at Ellegaard Göttingen Minipigs in Denmark and has been employed there for 18 years.
Content Partners
Academy of Surgical Research
- Encourage, foster, promote, and advance professional and academic standards, education, research, and development in the arts and sciences of experimental surgery.
- Promote, initiate, support, and accomplish academic and practical educational programs, cooperative research, and development in experimental surgery in the public interest.
- Promote humane use and treatment of experimental animals and prevent their use when other means can bring about the same scientific results.
- Cooperate with medical organizations, other scientific organizations, government agencies, and other interested parties in establishing, reviewing, and evaluating ethics, theories, practices, and research pertaining to surgical research and promotion of the product of surgical research for clinical application.
- Encourage the advancement of the field of surgery in all aspects, including research, education, and critical promotion of research products for clinical applications.
European Academy of Laboratory Animal Surgery (EALAS)
The EALAS was founded in 2021 by forward-thinking professionals who were concerned about the lack of a European networking platform and incomplete communication across the disciplines of surgical investigation.
EALAS is promoting the advancement of professional and academic standards, education and research in the arts and sciences of experimental surgery.
Central to the mission of the Academy is to promote the humane use and treatment of animals in research and to prevent their use when other means can meet the scientific objectives.
