Applications of Human Intestinal Organoid Cultures in Drug Discovery

Webinar Summary

Learn about the importance of the intestinal epithelium in early determination of drug toxicity
Discover applications of intestinal organoid cultures in:
- Drug discovery, including how organoid-derived intestinal cell cultures can be applied to assess the toxicity of potential therapeutic compounds
- Modeling barrier function
Explore intestinal organoid assays provided by Contract Assay Services, STEMCELL Technologies' contract research organization

Human intestinal organoids provide a scalable and highly predictive model system for studying the effects of novel therapeutics in vitro. Intestinal organoids contain the relevant cell types that constitute the intestinal epithelium and, as such, can be maintained in various states of proliferation or differentiation. These physiologically relevant models reveal the toxicity of compounds that can not be seen in Caco-2 cells, which are frequently used to model the intestine during drug development programs.

In this webinar, Dr. Victoria Conlin and Danny Leung from STEMCELL Technologies will describe, in detail, what intestinal organoids are, how they mimic the immunocytochemistry and morphology of the human gut epithelium, and how to use organoids for drug screening. They will also discuss the intestinal organoid assays offered by Contract Assay Services at STEMCELL Technologies.

Presenters

Victoria Conlin

STEMCELL Technologies (Business Operations)

Senior Manager, Contract Assay Services

Dr. Victoria Conlin is the Senior Manager of Contract Assay Services at STEMCELL Technologies. She obtained her PhD in Respiratory Physiology at the University of Newcastle upon Tyne, England. She has worked both in academia and industry researching areas of infectious disease and cell biology throughout various epithelial regions of the body.

Danny Leung

STEMCELL Technologies (Business Operations)

Scientist, Contract Assay Services

Danny Leung is the Lead Scientist in Assay Development for Contract Assay Services at STEMCELL Technologies. Danny has 30 years of experience in the field of assay development for pharmacology and toxicology.

STEMCELL Technologies Inc.

STEMCELL Technologies develops specialty cell culture media, cell isolation products and accessory reagents for life science research. Generate hPSC-derived cerebral organoids for a physiologically relevant in vitro model system with the STEMdiff Cerebral Organoid Kit. Use BrainPhys Neuronal Medium to culture active hPSC- and primary tissue-derived neurons in a physiological environment. The NeuroCult product line for primary and CNS-derived neural stem cells includes 30+ media and supplements, culture assays and differentiation kits. For human neurological disease modeling, the STEMdiff Neural System supports every step in your iPS-neural workflow, from neural induction to downstream differentiation.

Content Partners

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Topics

Pharmacology

Cell Culture & Characterization

Toxicology

Applications of Human Intestinal Organoid Cultures in Drug Discovery

Webinar Summary

Presenters

Victoria Conlin

Danny Leung

Sponsor

STEMCELL Technologies Inc.

Content Partners

Scientist.com

Topics

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