Circulating Nucleosome Quantification (Nu.Q) Technology for Monitoring Target Engagement and Adverse Events in Oncology Trials

Webinar Summary

Next-Generation Epigenetic Immunoassay for Quantitative Assessment of Circulating Nucleosomes
- Nu.Q Technology for determining levels of circulating nucleosomes
Pre-clinical through Clinical Development of Circulating Nucleosomes as Pharmacodynamic Biomarkers in Oncology Trials
- Histone PTMs at biomarkers for therapeutics targeting chromatin regulators
- Liquid biopsy to monitor target engagement of inhibitors of PRC2 subunits including histone methyl transferase EZH2 and its allosteric regulator EED
- Precision oncology strategy for selecting patients with H3K27me3 accumulation
- PD-1/PD-L1 checkpoint inhibitor combination with EZH2i/EEDi
Expanding Utility of Circulating Nucleosomes to Monitor/Predict Adverse Reactions to CAR-T cell therapy
- Neutrophil release of inflammatory mediators and decondensed DNA (NETosis) before and during the onset of cytokine release syndrome (CRS)
- Monitoring NETosis with Nu.Q

By the end of this discussion, attendees will:

Gain a nuanced understanding of the emerging opportunities in biomarker-driven, epigenetic therapeutic development.
Acquire insights into the future potential of nucleosome markers as versatile tools for cancer response and toxicity monitoring.

Eric A. Ariazi, PhD and Terry Kelly, PhD discuss how nucleosome-based markers are poised to accelerate oncology clinical trials, offering broader applications for monitoring both toxicity and efficacy.

This session explores the critical contributions of Nu.Q Technology to clinical epigenetics research, emphasizing its role in the identification and validation of biomarkers for epigenetic drug discovery. The technology's capability in monitoring treatment responses and its utility in elucidating the underlying mechanisms of disease processes are discussed.

Presenters

Eric A. Ariazi

Volition

Consultant

Eric A. Ariazi, PhD, is a distinguished Translational Medicine Scientist with 25+ years of experience spanning academia and industry.

Terry Kelly

VolitionRx/Volition America

Chief Innovation Officer/Chief Scientific Officer

Dr. Terry Kelly is the Chief Innovation Officer for VolitionRx and Chief Scientific Officer for Volition America.

Volition

Volition is a leading epigenetics biomarker company, renowned for its proprietary liquid biopsy immunoassay approach to profiling nucleosomes.

Content Partners

Scientist.com

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Topics

Pharmacology

Circulating Nucleosome Quantification (Nu.Q) Technology for Monitoring Target Engagement and Adverse Events in Oncology Trials

Webinar Summary

Presenters

Eric A. Ariazi

Terry Kelly

Sponsor

Volition

Content Partners

Scientist.com

Topics

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