Introduction to Bispecific Antibodies and Their Production

Sponsored by:

Date:

May 15, 2025

Time (PT):

11:00 AM

Duration (min):

In this webinar, Dr. Brady Wu discusses bispecific antibody drugs and their production.

First, he provides a comprehensive overview of the history and development of bispecific antibodies (BsAbs), including their structural biology and strategies like the "common light chain (cLC) approach" to resolve chain mispairing issues. Next, he elaborates on the mechanisms of action of BsAb drugs and challenges in selecting the most active bispecific candidates: currently, over 100 BsAb structural formats exist, with most designed using "knobs-into-holes (KIH)" engineering principles.

Regarding BsAb production, Dr. Wu highlights Biointron's expertise in molecular formats like KIH, IgG-scFv, and IgG-VHH, and presents solutions for addressing molecular mispairing and impurity removal during manufacturing. Additionally, he shares case studies and strategies to enhance antibody expression levels and optimize purification processes to meet diverse client requirements.

Finally, Dr. Wu introduces his company's infrastructure, R&D advantages in bispecific/multispecific antibody fields, and service features. This includes discussions on platform technologies for accelerating therapeutic development and customized solutions for complex antibody engineering challenges.

Presenters

Brady Wu

Biointron

Head of Protein Center

Dr. Brady Wu is a multidisciplinary scientist and biotech leader; now leading the Protein Science group at Biointron (2024–present), he drives ADC conjugation, developability assessment, and recombinant protein/antibody R&D efforts in the company.

Biointron

Founded in 2012 and certified to ISO 9001:2015, Biointron is a CRO specializing in antibody discovery, expression, and optimization services for biotech and pharmaceutical companies.

Content Partners

Scientist.com

Scientist.com is the world’s largest and first platform built for the intricacies of scientific outsourcing.

We help pharmaceutical and biotechnology organizations discover, engage, manage, and scale relationships with the providers that support every stage of the pipeline—from discovery and preclinical research to clinical development, manufacturing, medical affairs, and commercialization. Through a centralized platform, organizations can access a global network of 6,000+ providers, streamline sourcing and procurement workflows, maintain compliance, manage supplier relationships, and leverage data-driven insights to make faster, more informed decisions.

Today, Scientist.com supports more than 130 life science organizations, including 24 of the world's top 30 pharmaceutical companies, helping teams reduce operational complexity, accelerate timelines, and bring innovations to patients faster. Our mission is to make it possible to cure all human disease by 2050.

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Topics

Pharmacology

Antibodies

Introduction to Bispecific Antibodies and Their Production

Presenters

Brady Wu

Sponsor

Biointron

Content Partners

Scientist.com

Topics

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