Protein-Protein Interaction (PPI) Landscape - Sequence-to-Affinity Heatmaps for High-Throughput Antibody Optimization

Sponsored by:

Date:

November 11, 2025

Time (PT):

11:00 AM

Duration (min):

In this webinar, Dr. Jihye Jo introduces PPI (protein-protein interaction) Landscape, powered by PROTEINA's single-molecule SPID platform.

PPI Landscape transforms antibody libraries into sequence-to-affinity heatmaps, capturing 5,000 KD-precision data points per run with SPR/BLI-equivalent accuracy. Within just two weeks, the platform completes the entire workflow‚Äîfrom DNA library synthesis to mammalian (HEK/CHO) expression and single-molecule KD measurement‚Äîall without purification.

This quantitative Deep Mutational Scanning (qDMS) approach reveals how every mutation within the antibody CDRs affects binding affinity, guiding combinatorial library design across inter- and intra-CDR regions.

As a data-driven, high-throughput, fee-for-service solution, PPI Landscape enables rapid affinity maturation and tuning, delivering optimized antibody sequences with sub-nanomolar to picomolar affinities‚Äîat unmatched speed, scale, and precision.

Presenters

Jihye Jo

PROTEINA (High-Throughput Antibody Engineering Platform)

Director

Dr. Jihye Jo is Director of the High-Throughput Antibody Engineering Platform at PROTEINA, where she leads the development of SPID, a single-molecule fluorescence imaging technology that enables high-throughput antibody characterization and AI-driven antibody design.

PROTEINA

PROTEINA (KOSDAQ: 468530) is a biotechnology company redefining antibody engineering through single-molecule precision. Its proprietary SPID (Single-molecule Protein-Protein Interaction Detection) platform enables high-throughput, quantitative analysis of complex protein interactions at molecular resolution.

Content Partners

Scientist.com

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We help pharmaceutical and biotechnology organizations discover, engage, manage, and scale relationships with the providers that support every stage of the pipeline—from discovery and preclinical research to clinical development, manufacturing, medical affairs, and commercialization. Through a centralized platform, organizations can access a global network of 6,000+ providers, streamline sourcing and procurement workflows, maintain compliance, manage supplier relationships, and leverage data-driven insights to make faster, more informed decisions.

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‍

Topics

Pharmacology

Protein Sciences

Protein-Protein Interaction (PPI) Landscape - Sequence-to-Affinity Heatmaps for High-Throughput Antibody Optimization

Presenters

Jihye Jo

Sponsor

PROTEINA

Content Partners

Scientist.com

Topics

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