Dr. Anna Borgström and Dr. Frauke Greve present the latest advancements in hepatic safety assessment using 3D liver spheroids.
Drug induced liver injury (DILI) presents a significant challenge for the pharmaceutical industry and regulatory authorities during preclinical and clinical phases, and in the post-marketing stage of a drug's life cycle. Using animal and 2D models to predict human DILI has known issues as they lack full physiological relevance. The need for better predictive drug development tools is obvious, particularly in light of the rapid growth of, and increasing interest in advanced new therapeutic modalities.
In this webinar, Dr. Anna Borgström (Senior Scientist, Liver Safety, InSphero) presents the latest advancements in the hepatic safety assessment of drugs using human 3D liver spheroids - stable primary cell-based systems that accurately model the human liver in vitro. In the second part of the session, Dr. Frauke Greve (Senior Product Manager, Cell-culture technologies, InSphero) addresses the key technologies that brought the DILI model to industry application - backing up biological relevance with reproducible and scalable 3D cell culture systems.
Presenters
Anna Borgström
Dr. Anna Borgström is a cell and molecular biologist by training, with over 10 years of experience, working on a variety of scientific topics and sharpening her skills in cell biology, cell-based assays, and diagnostic assay development. In early 2022 she joined InSphero as Senior Scientist, leading the customer-based service studies, providing solutions for liver safety inquiries, and establishing 3D models as an alternative to in vivo testing. In her role Anna supports the development of high-throughput compatible assays and is working towards the development of next-generation testing methods for drug toxicity. Dr. Borgström earned her PhD at the University of Zurich in 2013.
Frauke Greve
Dr. Frauke Greve is an experienced technology professional combing technical skills, analytical thinking, and perseverance. She joined InSphero in 2015 as part of the Technology and Platforms team. In her role as a Senior Product Manager for the Cell-culture consumables Dr. Greve works closely with researchers to develop new technologies for 3D cell handling and the various, specially designed ultra-low attachment Akura™ Spheroid Microplate Solutions. Frauke studied Electrical Engineering at the Federal Institute of Technology (ETH) and completed her PhD in Microelectronics in 2006.
Sponsor
InSphero
Content Partners
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