In this talk, we highlight epigenomics as a dynamic regulatory layer beyond genetics and demonstrate how minimally invasive liquid biopsies can provide multimodal biomarker readouts.
We first introduce our expanded portfolio, which now extends beyond cfDNA methylation to encompass chromatin and circulating nucleosome quantification, as well as comprehensive cfRNA profiling from liquid biopsy derived material. Building on this, we present real-world case studies demonstrating how cfDNA methylation can be leveraged for treatment response monitoring. We also illustrate how circulating nucleosomes and their histone PTMs can be used to assess epidrug effects and support the optimization of clinical trial decision-making. Finally, we show how comprehensive cfRNA-based transcriptomic profiling can be applied to cancer diagnostics.
Throughout, we emphasize the value of integrating multiple epigenomic readouts, combined with AI/ML analytics, to enhance mechanistic insight, improve biomarker performance for diagnostic applications including early detection, disease classification, and risk stratification, and ultimately accelerate translational research and drug development.
Presenters
Matteo Tosolini
Dr. Matteo Tosolini is a Biopharma Business Development Manager for EMEA at Hologic Diagenode with strong scientific backgroud in epigenetics and marketing. He earned his PhD in Stem Cell Epigenetics in Université Paris-Saclay. He then joined Diagenode as Research Scientist first and then moved into Marketing and Product Managment.
Jessica Apulei
Dr. Jessica Apulei is a Scientific Liaison Manager at Hologic Diagenode with strong expertise in epigenetics technologies and applications. She earned her PhD in Neurobiology and Epigenetics in Paris at the Collège de France and completed her postdoctoral research in Boston at Harvard University. Her work focuses on advancing cfDNA and epigenomic technologies to support biomarker discovery, translational research, and precision medicine.
Sponsor
Diagenode
Content Partners
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