A 2-part webinar for scientists interested in novel drug delivery methods for basic research, drug discovery and development. Learn about novel infusion technologies and how challenges in physiological monitoring and drug delivery are being overcome by implantable and programmable devices.
Dr. Doyle discusses how vitamin B12 conjugation of Peptide YY3-16 decreases food intake compared to native Peptide - YY3-36. Learn how challenges to peptide-based therapies, such as rapid clearance, ready degradation by hydrolysis/proteolysis and poor uptake can be overcome by using the iPrecio implantable pump.Christian Schnell, Lab Head of in-vivo Pharmacology and Oncology Research at Novartis in Basel, Switzerland presents data from multiple species that show how differences in blood pressure, heart rate and acute stress impact drug activity and how dosing a pre-trained animal can influence hemodynamic parameters.
Additional References:
Discovering and Developing Molecules with Optimal Drug-Like Properties Editors: Allen C Templeton, Stephen R. Byrn, Roy J Haskell, Thomas E. PrisinzanoISBN: 978-1-4939-1398-5 (Print) 978-1-4939-1399-2 (Online) 27 Sep 2014  Discovery Formulations: Approaches and Practices in Early Preclinical DevelopmentShobha N. Bhattachar, David M. Bender, Stephanie A. Sweetana, James A. WesleyDiscovering and Developing Molecules with Optimal Drug-Like PropertiesAAPS Advances in the Pharmaceutical Sciences Series Volume 15, 2015, pp 49-94 Chapter 2, 27 Sep 2014Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and ProcessesRoy J. Haskell, Kimberly A. Foster, Ching Kim Tye, Michael MorgenDiscovering and Developing Molecules with Optimal Drug-Like PropertiesAAPS Advances in the Pharmaceutical Sciences Series Volume 15, 2015, pp 95-140 Chapter 3, 27 Sep 2014
Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical ResearchTove Tuntland, Brian Ethell, Takatoshi Kosaka, Francesca Blasco, Richard Xu Zang, Monish Jain, Ty Gould, Keith Hoffmaster.Front. Pharmacol., 28 July 2014
Optimising in vivo pharmacology studies—Practical PKPD considerationsJohan Gabrielsson, A. Richard Green, Piet H. Van der GraafJournal of Pharmagological and Toxicological Methods, Volume 61, Issue 2, March-April 2010, pp 146-156.
Syracuse University Magazine Article on Dr Robert Doyle's Research
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