Hematopoietic Stem Cell Fitness and Function During Sickle Cell Disease

Webinar Summary

Explore evidence regarding the risk of clonal hematopoiesis and AML/MDS following transplantation in sickle cell disease patients
Learn about damage to the HSC pool in sickle cell patients and mice
Discover products and resources to support your HSC workflows

Chronic insults, such as inflammation and replicative stress, impair and exhaust blood-sustaining hematopoietic stem cells (HSCs), leading to dysfunction and selection for leukemia-associated mutations. Dr. McKinney-Freeman's laboratory is currently studying how sickle cell disease (SCD), an inherited hemolytic anemia with a large inflammatory component and increased hematopoietic demand, compromises the fidelity and function of hematopoietic stem cells (HSCs) in both mice and individuals with SCD. Mounting evidence indicates that SCD patients may experience enhanced rates of clonal hematopoiesis, as well as MDS and AML at baseline and following allogeneic HSC transplantation or autologous HSC gene therapy. Considering that these are the only curative therapies for SCD, it is important to better understand and prevent SCD-induced insults to HSCs and their microenvironment.

In this webinar, Dr. McKinney-Freeman from St. Jude Children's Research Hospital describes, in detail, what her laboratory has learned about how SCD affects HSCs.

Presenters

Shannon McKinney-Freeman

St. Jude Children’s Research Hospital (Hematology)

Member

Dr. Shannon McKinney-Freeman works in the Department of Hematology at St. Jude, where she focuses on understanding the fundamental biology of blood-forming stem cells. She is passionate about creating an inclusive and exciting lab environment, characterized by collegiality and scientific excellence.

STEMCELL Technologies Inc.

STEMCELL Technologies develops specialty cell culture media, cell isolation products and accessory reagents for life science research. Generate hPSC-derived cerebral organoids for a physiologically relevant in vitro model system with the STEMdiff Cerebral Organoid Kit. Use BrainPhys Neuronal Medium to culture active hPSC- and primary tissue-derived neurons in a physiological environment. The NeuroCult product line for primary and CNS-derived neural stem cells includes 30+ media and supplements, culture assays and differentiation kits. For human neurological disease modeling, the STEMdiff Neural System supports every step in your iPS-neural workflow, from neural induction to downstream differentiation.

Content Partners

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Topics

Cell Culture & Characterization

Pharmacology

DNA & RNA

Hematopoietic Stem Cell Fitness and Function During Sickle Cell Disease

Webinar Summary

Presenters

Shannon McKinney-Freeman

Sponsor

STEMCELL Technologies Inc.

Content Partners

Scientist.com

Topics

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