Join Vincent Prevot, PhD as he dives into the development and establishment of the gonadotropin-releasing hormone (GnRH) system and the importance of its first postnatal activation.
Pulsatile secretion of gonadotropin-releasing hormone (GnRH) is essential for activating and maintaining the function of the hypothalamic-pituitary-gonadal (HPG) axis, which controls the onset of puberty and fertility. Two provocative recent studies suggest that, in addition to controlling reproduction, the neurons in the brain that produce GnRH are also involved in the control of postnatal brain maturation, odor discrimination, and adult cognition.
Vincent focuses on the GnRH system and first postnatal activation, a phenomenon known as minipuberty, to its later functions, reproductive and non-reproductive. In addition, he discusses the beneficial effects of restoring physiological, i.e. pulsatile, GnRH levels on olfactory and cognitive alterations in Down syndrome and preclinical models of Alzheimer's disease, as well as the risks associated with long-term continuous, i.e. non-physiological, GnRH administration in certain disorders. Finally, he discusses the intriguing possibility that pulsatile GnRH therapy may hold therapeutic potential for the management of some neurodevelopmental cognitive disorders as well as pathological aging in the elderly.
Presenters
Vincent Prevot
Vincent Prevot, PhD focuses his research on brain circuits that control reproduction and metabolism and the neural pathways through which they respond to peripheral information, and the role of the early postnatal activation of reproductive circuits during a period called minipuberty on brain development and aging, including cognitive aging.
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