Protocol Preview: Creating an Artificial Human Thymus in Mice Blog post by Jasmin Skinner Have you ever wanted to model T cell immunity in mice? In this blog post, we review a recent publication from Nature Methods outlining the methodology behind creating an artificial human thymus in humanized mice [2].

Problems with modeling the immune response in mice

Immunodeficiencies, whether present from birth or acquired throughout life, can be debilitating diseases that severely reduce quality of life. These faulty immune responses can result from a dysregulation of the thymus, a gland primarily responsible for the maturation of lymphocytes. While effective treatments exist for a few immunodeficiency disorders, the majority of treatment options are temporary fixes, in part due to a lack of preclinical models that can accurately predict immune responses in humans [1]. However, a novel model recently published in Nature Methods has potential to greatly improve future immune response studies [2]. https://insidescientific.com/wp-content/uploads/2022/03/Quick-and-Easy-Isolation-of-T-Cells-and-Other-Immune-Cells-from-Large-Volume-Samples_F1.jpg

Quick and Easy Isolation of T Cells and Other Immune Cells from Large-Volume Samples

Join Amanda Vanden Hoek, PhD, and Vesna Posarac, MSc, as they present two novel platforms for the efficient isolation of immune cells from large volume samples. WATCH NOW

Modeling T cell immunity in humanized mice

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