Pharmacology

Advanced Screening Strategies for Molecular Glue Discovery

AI Is Expanding What's Possible in Drug Discovery. Operational Friction Still Determines How Fast It Happens.

The Science of the "Gut Feeling": Why Techs are a Lab's Best Diagnostic Tool

Cell Line-Derived Xenografts: A Reliable Platform for Preclinical Cancer Drug Testing

From the Colony to the Roadmap: The FDA's New Stance on NAMs and Why it Matters

Evolving Secondary Pharmacology: Functional, Dose-Response Safety Panels For Every Stage Of Discovery

Advancing the Manufacture of Mesenchymal Stromal Cells and Derived Extracellular Vesicles in Stirred-Tank Bioreactors Through Enhanced Bioprocess Control

From Clinical Data to Actionable Assets for Pharmaceutical R&D

Screening the Unscreenable: Expanding the Reach of Drug Discovery

Improving Preclinical Decision-Making in Obesity and CKD with Translational In Vivo Phenotyping

Detecting Early Synaptic Failure in Prion Disease Using Organoid Models

Bridging Mouse Models and Human Inflammatory Bowel Disease: in vivo Pharmacology, Histology and Biomarkers

Translational Success in Inflammasome Drug Discovery: How Advanced Models and Integrated Assays Can Reduce Attrition

High-Throughput-qPCR and Transcriptomics: Powering the Next Generation of Drug Discovery

Beyond Exposure: Integrating PK/PD for Translational Predictive Power

Improving Confidence in Thyroid Hormone Disruption Assessment Using a Novel Human-Relevant In Vitro Model

How to Avoid Expensive Redesign Cycles in Antibody Discovery

Accelerating Antibody Discovery: Integrating Microfluidics, HT Expression, and Early Developability Platform

Scaling AAV9 Manufacturing: A Blueprint for Clinical-Grade Gene Therapy Production

Fulfilling the Gap: Innovative Critical Reagents for Non-Human Primate Preclinical Studies

Advancing ADC Development: Leveraging AI and Translational Preclinical Models to Improve Clinical Predictability

From Biopsy to Better Decisions: Patient-Derived Organoids Predict Treatment Response in Metastatic Colorectal Cancer

Human iPSC-Derived Sensory Neurons for Functional Sensory Biology and Pharmacology Research

Precision in Human Biological Samples: Leveraging Regulatory Rigor and Deep Data for Advanced Disease Research

Epigenomics at 360 in Liquid Biopsy: Approaches and Case Studies for Biomarker Discovery and Drug Development

Recent Advances in Crystalline Polymorphism Research in Drug Development

Accelerating Conjugation Process Development for Next-Generation ADCs: Key Considerations and Platform Strategies

De-Risking Immunotherapy Targets with Next-Gen HLA Discovery Platforms

Next-Generation TCR-Like Antibodies With Improved Specificity Profiles

The Sound of Science: Mapping the Tumor Microenvironment for Advanced Therapeutic Strategies

ADC Payload-Linker CMC Process Development Strategy

Selectivity Profiling: Unbiased Analysis of Compound Selectivity in Drug Discovery

ADCs on The Horizon: The Performance and Prospect of Cell Line Development Platform ‚Äî AmigoCHO

Building New Approach Methodologies for Angiogenesis and Vascularized Models

Clinical Applications of Optical Cerebral Blood Flow Imaging

Using ALS Patient-Derived Motor Neurons to Study TDP-43 Mislocalization

Vevo Ask The Experts: Oncology Imaging

hiPSC-Cardiomyocyte Platforms Enabling Comprehensive Cardiac Toxicity and Drug Efficacy Evaluation

Protein-Protein Interaction (PPI) Landscape - Sequence-to-Affinity Heatmaps for High-Throughput Antibody Optimization

Combination Therapy for Glioblastoma: A Personalized, AI-Driven Approach

In Vivo panCAR Therapy Using Circular RNA for the Treatment of Autoimmune Disease

Non CYP Mediated Metabolism Pathways and In Vitro Evaluation Strategies

Human Biological Samples in Research: Quality, Compliance, and Clinical Relevance

From Single Domain to Single B: Leveraging Biointron's Expertise for Antibody Discovery Success

Enhance Your Tissue Processing Efficiency with the STEMprep Tissue Dissociator

Beyond Checkpoints: Strategic Use of CDX Models in Emerging IO Therapies

Uniting biology and digital drug discovery to identify new therapeutic opportunities in neurodegeneration

Exploring the iPSC-Derived Neuronal-Glia Co-culture System: A Powerful Drug Discovery Platform for Studying Neurodegenerative Diseases

Vaccine-Boosting CAR T Cells Against Solid Tumors

Launch Event: Propelling Boundaries - Innovative Technologies in Early Drug Discovery

Novel Applications of the Cellular Thermal Shift Assay (CETSA) Provide New Insights for Drug Discovery

Advances in Preclinical Research using Human Co-culture Models: Applications in Immunology, Infectious Disease, and Oncology

Integrating Regulatory Guidance and Sustainable Skin Procurement for Consistent Execution of In Vitro Permeation Testing

Cell-Based Assays for Immuno-oncology

Artificial Intelligence in Preclinical Research: Pathology, Biospecimens, and Model Selection

CAR Finder - A Platform for Rapid CAR T Cell Screening

CRISPR Gene Editing in Primary T Cells: A Case Study in the Fight Against HIV

Fresh or Cryopreserved Leukopaks? Assessing the Impact of Different Storage Conditions on Leukopak Stability

The Hidden Variable in Your Intestinal Organoids: Enhancing Differentiation for a More Predictive Model

Biomarkers from Bench to Bedside: Tools, Targets, and Translational Insights

Leveraging Genomic, Preclinical, and Drug Response Data in the Age of AI

Introduction to Bispecific Antibodies and Their Production

Integrating Functionalized Multi-omics in Oncology Drug Discovery

Improved Clearance Predictions for Aldehyde Oxidase Substrates Using TruVivo, a Novel Human Hepatocyte Model

Breaking the Bottleneck: Harnessing Proteomics Services to Overcome Challenges in Clinical Research

Discovery and Engineering of High-Affinity Soluble T Cell Receptors via a High-Throughput Yeast-Based Platform

Innovative Rabbit Antibodies and Engineering for Therapeutics and Diagnostics

Towards Eliminating Small Molecule Toxicity: Axiom's AI Models for Clinical Safety Assessment

High-Quality Mobilized Leukopaks to Enhance Your Cell and Gene Therapy Research and Development

Considerations in Tissue Acquisition and Characterization for the Development of Long-Term Tumoroid Models

Challenges and Opportunities for Treatment of Metastatic Breast Cancer

Hormonal and Chromosomal Influences on Autoimmunity and Lupus

Advancing Your Innovation: Navigating the Complexity of Stable Cell Line Development

Empowering Drug Hunters with High-Throughput Protein Crystallography

Arrayed CRISPR screening for phenotypic discovery at the MRC-AstraZeneca-University of Cambridge Joint Functional Genomics Screening Laboratory (FGSL)

Unraveling Immunotherapy Resistance in Advanced Melanoma: Novel Insights from Longitudinal Spatial Multiomics Studies

Supporting the Development of Biologics Through the IND-Enabling Studies and Clinical Phases

Licensing Biological Materials: Crucial Considerations for Preclinical Researchers

Spatial Biology and the Gastrointestinal Tract: Unveiling Cellular Landscapes and Disease Mechanisms

Meeting Ethical & Regulatory Requirements When Using Human Biological Specimens

Deconstructing the Effects of Dietary Fat on Intestinal Cellular Networks

From Bench to Clinic: Decoding the IND Roadmap for Innovative Cell and Gene Therapies

The ADMET Toolkit: Impact on Compound Design and Optimisation

Reprogramming the Brain Tumor Microenvironment to Enhance Anti-Tumor Immunity

Illuminating Immunohistochemistry: Right-sizing Your Validation and Regulatory Strategy

A New Approach to Vector-Free CRISPR Editing Starting From Single Cells

Using In Vitro Assays to Model Complex Biology with PhenoVista's Assay Services

Bringing Oncology Intelligence to Early Drug Development With AI-Powered Response Predictions

Hematopoietic Stem Cell Fitness and Function During Sickle Cell Disease

Illuminating Immunohistochemistry: From Biomarker to Clinical Trial Assay

Implementing the Colony-Forming Unit (CFU) Assay As a Potency Assay for Hematopoietic Cell Therapy Products

Applications of Humanized Mice in the Evaluation of Antibody-Drug Conjugates to Treat Autoimmune Diseases

Discover the Freshness of Frozen PBMCs - An Assessment of Cryopreservation Impact on T Cell Activation and Phenotype

Molecular Signals Mediating Increases in Muscle Size and Function

Innovative Approaches to Assessing Thyroid Disruption: The 3D Human Thyroid Microtissue Model

Circulating Nucleosome Quantification (Nu.Q) Technology for Monitoring Target Engagement and Adverse Events in Oncology Trials

Preclinical Animal Models of IBD, GVHD, and Pulmonary Disease

Applications of Human Intestinal Organoid Cultures in Drug Discovery

The Translational Utility of Ultrasound and Photoacoustics in Head and Neck Oncology

Next-Generation Safety Assessment Tools for Advancing In Vivo to In Vitro Translation

Strategies to Optimize Commercialization of Oncology Treatments for Younger Adults

Organoid Meets Microelectrode Array (MEA) - Accelerating Drug Discovery and Development

How to Better Predict Potential Drug Interactions Early in the Discovery Process

Indwelling Portal Vascular Access Ports: Application, Advantages, and Management

Advancing Disease Modeling for Drug Discovery by Modulating iPSCs with CRISPR and Neuronal Differentiation

A Ready-to-Analyze High-Plex Spatial Signature Development Workflow for Cancer Immunotherapy

Weekly News Roundup - RSV Breakthrough Data, Psychedelic Approvals on the Horizon, and Major FDA Policy Shifts

Making Real-World Data Research-Ready

Podcast Q&A: Clinical Outcomes Assessments and Training

Podcast Q&A: Patient-Centered Real-World Evidence in Rare Diseases

#ExpertAnswers: Jack Vanden Heuvel on Prediction Drug-Drug Interactions Early

#ExpertAnswers: Lorcan Sherry and Aditya Pratapa on Analyzing Multiplex Immunofluorescence Images

#ExpertAnswers: Conor McCartin on Phage Display Technologies

#ExpertAnswers: Matt Silva on Cryo-Fluorescence Tomography for Immunotherapy Research

#ExpertAnswers: Arutha Kulasinghe on Single-Cell Spatial Phenotyping for Biomarker Discovery

#ExpertAnswers: Renee Brissette, PhD on Custom Antibody Generation

The Future of Diversity in Clinical Trials: Real-World Evidence

#ExpertAnswers: Jack Vanden Heuvel on Nuclear Receptor Profiling

#ExpertAnswers: Steven Loo-Yong-Kee on CRISPR-Edited T Cells

#ExpertAnswers: Nataliia Beztsinna and Marten Hornsveld on Pre-Clinical Immuno-Oncology

#ExpertAnswers: Frauke Greve and Anna Borgstr√∂m on Hepatic Safety Using 3D Liver Spheroids

Talking Real Science with Ellie Siebeneck

Industry Insights with Crown Bioscience: Analyzing the Suppressive TME in In Vitro Based Assays

#ExpertAnswers: Audrey Dubourg and Gareth Guenigault on the Organ-On-A-Chip Approach

#ExpertAnswers: Marrit Putker, Saskia De Man, and Pirouz Daftarian on T Cell-Directed Immunotherapy

Industry Insights with Crown Bioscience: Targeting T Cells Within the Cancer Immunity Cycle

#ExpertAnswers: Dudley Lamming on the Influence of Sex and Genetic Background on Diet

#ExpertAnswers: Ejvind Mørtz on Protein Analysis

#ExpertAnswers: Andrew Taylor on Drug Metabolism

Industry Insights with Amy Sheng on Nanobodies: An Important Tool for the Next Generation of Tumor Diagnostics and Therapeutics

Talking Real Science with Chris Perry

#ExpertAnswers: Bonnie Lun on Single-Domain Antibodies for Research

#ExpertAnswers: Peter Ansell and Marian Navratil on Gene Expression Profiling

#ExpertAnswers: Edward LeCluyse and Paul Gallant on a Novel Hepatic Triculture System

#ExpertAnswers: Franck Lebrin and Denis Vivien on Ultrasound Imaging in Stroke and Neurovascular Diseases

#ExpertAnswers: Yuning Chen on Antibody Production

Industry Insights with Yuning Chen on Recombinant Proteins

#ExpertAnswers: Bin Xie on Drug Development for Immuno-Oncology

#ExpertAnswers: Anuj Kalsy and Robert Snyder On The Variant-Rich Biobank

#ExpertAnswers: Andrea Bonetto on the Musculoskeletal Complications of Cancer and its Treatments

#ExpertAnswers: Pierre Pouget and Serge Picaud on Functional Ultrasound Imaging

#ExpertAnswers: Luke Holloway on Protein Characterization

#ExpertAnswers: Alexandra Lubin & Jason Otterstrom on Automated Microscopy

#ExpertAnswers: Marcela Maus on Inflammation and Immunophysiology

#ExpertAnswers: Christian Schnell on Pharmacology Studies in Oncology Research

#ExpertAnswers: Christopher Axelrod & Sander Kooijman on Rodent Models of Pharmacotherapy and Chronotherapy

#ExpertAnswers: Sophie Pezet & Benjamin Vidal on Functional Ultrasound Imaging

#ExpertAnswers: Matt Kaeberlein on Aging Science

#ExpertAnswers: Lais Berro on the Behavioral Effects of Benzodiazepines

#ExpertAnswers: Ania Jastreboff on Obesity

#ExpertAnswers: Fred Beasley on Obesity

#ExpertAnswers: Kenneth Dyar & Joanna Moore on Automated Home Cage Activity Monitoring

#ExpertAnswers: Chris Ward, Ramzi Khairallah & Sharon Hesterlee on Muscular Dystrophy

#ExpertAnswers: Artem Shatillo & Zsolt Lenkei on Functional Ultrasound Imaging

#ExpertAnswers: Miroslaw Janowski and Piotr Walczak on Imaging for Precision Medicine

#ExpertAnswers: Robert Gould and Michael Girand on Utilizing EEG to Study Sleep, Substance Use and CNS Disorders

#ExpertAnswers: John Cirrito & Candace Rhode-Johnson on Micro-dialysis and Neuroscience

#ExpertAnswers: Melanie White on Isolated Langendorff Heart Principles

#ExpertAnswers: Marcio Furtado on EEG Monitoring in the Study of Experimental Epilepsy

#ExpertAnswers: Keshari Thakali and Aaron Stupica on Maternal Obesity Effects on Offspring

#ExpertAnswers: Jay W. Mason & Mike Gralinski on ECG Interval and Arrhythmia Assessment

#ExpertAnswers: Daniel Lark & John Lighton on Behavioral Neuroscience

#ExpertAnswers: David Culp and Christine van Hover on Retinal Imaging

#ExpertAnswers: José Gadea on Implantable Pumps

#ExpertAnswers: Robert Doyle on Novel Drug Delivery Methods

#ExpertAnswers: Christian Schnell on Drug Delivery Methods

#ExpertAnswers: Brian Brockway and Robert Hamlin on Wireless Monitoring Technology

Industry Insights with Amrik Singh from Cell Signaling Technology